#1: For Maximum Efficacy, Choose a Supplement for Your Mastiff with Multiple Active Ingredients

When most people think of a joint supplement for their mastiff, glucosamine comes to mind. And while glucosamine is the most popular active ingredient, other powerful nutraceuticals include MSM, chondroitin, and turmeric (curcumin). If your supplement contains only one or two of these, you may be missing potential benefits. Different dogs respond to different treatments, so when in doubt, offer a broad spectrum of nutrients.

#2: Always Check The Amount of Active Ingredients

If the quantity of active ingredients (in milligrams) is not made available, the product likely contains low levels that are unlikely to have a therapeutic effect on your mastiff’s joints. As a rule of thumb, your dog should receive 20 mg of glucosamine daily for each pound they weigh. Budget oriented joint supplements (often in the $15-20 a bottle range) often contain levels too low to make any serious impact on your dog’s joint health. In addition, dry dog food manufacturers have begun including trivial amounts of glucosamine in their products in an attempt to woo consumers. Make sure your dog receives enough to matter!

#3: Always Buy Made In USA

While you’d expect that most pet stores would have transitioned to only carrying consumable products that are made in the USA, this is simply not the case. Many budget oriented pet stores, online retailers, and grocery stores still carry inferior supplements made in factories outside the USA with far lower production standards.

#4: Decide If You Want An Arthritis Supplement with or Without Hemp for Your Mastiff

The last few years has brought about exciting advancements in the use of Hemp for dogs. Several clinical trials have shown Hemp can improve the mobility of arthritic dogs. Some brands have begun to offer their Hip & Joint supplements with Hemp or without Hemp.

#5: Results Will Vary Based on Your Mastiff’s Age and Condition

Ideally, a joint supplement regimen should begin before signs of pain are present in your mastiff. (ideally around 5 years of age, although large breeds may need earlier) In reality, however, we often don’t consider the need until signs of pain are apparent. If your dog is already showing signs of distress, a joint supplement can still offer substantial relief. However, it may take 1-2 months to show signs of improvement.

#6: Taste and Format Matters

The best joint supplement in the world is worthless if your dog refuses to eat it. The most popular formats of delivery for joint supplements are liquid, tablet chews, and soft chews, each with their own benefits and drawbacks. When it comes to palatability, soft chews and liquids tend to please the most canine palates. Because a soft chew can contain a wider variety of nutraceuticals (see item #1) it’s our preferred method.

Where Our Research Led Us (Our Preferred Joint & Joint Supplement for Mastiffs)

Our research in hip & joint supplements for dogs led us to develop & recommend the Happy, Healthy line of canine joint care supplements. An added bonus of this brand is that each purchase goes towards helping provide food for animal shelters in need.

Frequently Asked Questions About Choosing the Best Joint Supplement for a Mastiff

What should I look for in a joint supplement for my Mastiff?
Look for key ingredients such as glucosamine, chondroitin, MSM (methylsulfonylmethane), and hyaluronic acid. These components help support cartilage repair, reduce inflammation, and improve mobility—especially important for large breeds like Mastiffs that are prone to joint issues.

Are joint supplements necessary for younger Mastiffs?
Yes, early prevention is key. Starting your Mastiff on a joint supplement as early as 12–18 months old can help delay the onset of arthritis or hip dysplasia, which are common in large breeds due to their rapid growth and weight-bearing joints.

Can joint supplements help with hip dysplasia in Mastiffs?
While not a cure, joint supplements can significantly reduce inflammation and discomfort associated with hip dysplasia. They support joint structure and function, often improving your dog’s mobility and quality of life.

Is glucosamine alone enough for my Mastiff’s joint health?
Glucosamine is a great start, but for optimal support, look for a comprehensive supplement that also includes chondroitin, MSM, omega-3 fatty acids, and antioxidants. A multi-ingredient formula offers better long-term protection and joint maintenance.

How long does it take to see results from joint supplements?
Most dog owners begin to notice improvements in their Mastiff’s movement and comfort within 4 to 6 weeks of consistent use. However, individual responses may vary depending on the severity of joint issues and the supplement formulation.

Are there any side effects to giving joint supplements to Mastiffs?
Side effects are rare but can include mild gastrointestinal upset like diarrhea or gas. Always start with the recommended dose and consult your vet before adding any supplement, especially if your Mastiff has other health conditions.

Do I need a prescription to buy joint supplements for my Mastiff?
No, most joint supplements are available over-the-counter or online. However, it’s still a good idea to talk to your veterinarian for guidance on the best product and dosage for your Mastiff’s specific needs.